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TL;DR
The researchers conducted an in vivo experiment involving I/R surgery and resveratrol administration.
Food Science & Nutrition · 7 authors, 4 centres
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The researchers conducted an in vivo experiment involving I/R surgery and resveratrol administration.
The researchers conducted an in vivo experiment involving I/R surgery and resveratrol administration. The central results indicated that aged mice hearts exhibited decreased autophagy (lower Beclin1, LC3 II) and increased apoptosis (higher Bax, Caspase-3 activity; lower Bcl-2), which correlated with increased vulnerability to I/R injury. Resveratrol treatment reversed these changes, improving cardiac systolic function after I/R. The proposed mechanism involves resveratrol increasing SIRT1 activity, which promotes the deacetylation of Beclin1, enhances autophagy, and subsequently inhibits the apoptotic pathway. The findings suggest resveratrol may have therapeutic potential for age-related cardiac I/R injury by modulating autophagy-apoptosis balance.