Animals : an Open Access Journal from MDPI · 11 authors, 5 centres
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This preclinical study in mice synthesized Schisandra chinensis polysaccharide-conjugated selenium nanoparticles (SCP-Se NPs) and tested their effects on LPS-induced intestinal injury. The main finding was that SCP-Se NPs more effectively alleviated diarrhea, tissue damage, and inflammatory cytokine expression compared to SCP alone, but the study is limited to animal models and may not directly apply to humans.
Enteritis is a common disease in livestock and poultry, often caused by Gram-negative bacterial infection. Schisandra chinensis polysaccharide (SCP) has therapeutic potential, but its bioavailability is low. Selenium nanoparticles (Se NPs) can enhance bioactivity, so SCP-conjugated Se NPs (SCP-Se NPs) were developed. Methods: SCP was extracted and purified from Schisandra chinensis. SCP-Se NPs were synthesized via sodium selenite reduction and characterized by TEM, XRD, EDX, FTIR, and stability tests. In vivo, 28 mice were divided into four groups: blank control, LPS model, SCP, and SCP-Se NPs. After 14 days of treatment, LPS was injected, and intestinal injury was assessed via DAI scoring, HE staining, IHC for ZO-1, and qRT-PCR for inflammatory cytokines. Key Results: SCP-Se NPs were amorphous, spherical, 121 nm in diameter, and stable at 4°C for 14 days. They significantly reduced LPS-induced diarrhea, intestinal tissue damage, and tight junction destruction compared to SCP. Inflammatory cytokines (TNF-α, IL-1β, IL-6) were decreased more effectively by SCP-Se NPs than by SCP, with p < 0.05 for significance. Limitations: The study is preclinical, using a mouse model, with a small sample size of 28 mice. It does not test in humans or livestock directly, and the LPS-induced model may not fully replicate natural enteritis. Implications: SCP-Se NPs show promise for preventing and treating enteritis in livestock and poultry, but further research is needed for clinical application.
