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TL;DR
Mixotrophic acclimation led to upregulated acetate assimilation and photosynthetic genes, resulting in more active growth compared to autotrophic acclimation, with the effect being most pronounced at early culture stages.
Life · 4 authors, 3 centres
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Mixotrophic acclimation led to upregulated acetate assimilation and photosynthetic genes, resulting in more active growth compared to autotrophic acclimation, with the effect being most pronounced at early culture stages.
Cells pre-cultivated under mixotrophic conditions showed higher expression of acetate synthase genes (ACS1, 2) and citrate synthase 1 (CIS1) at the onset of growth, enabling faster metabolic activation. Mixotrophic-acclimated cells also exhibited more active photosynthetic genes including RBCS1, consistent with maintained photosynthetic machinery. Autotrophic acclimation upregulated sugar exporter genes HXT1 and MEX1, reflecting dependence on photosynthetically fixed carbon. The effect of acclimation was more pronounced after mixotrophy, especially at the beginning of culture growth, while autotrophic acclimation did not show a clear relationship.