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other·preclinical research, biomedical research, nutrition, geriatrics, micronutrients·PMC10141758

Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice

Life · 4 authors, 2 centres

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TL;DR

Turmeric extract significantly improved body weight loss, tibialis anterior weight, and modulated key atrophy-related gene expression in multiple muscle types.

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The study measured body weight, muscle weights, and mesenteric fat at 36 weeks, along with transcriptomic and proteomic analyses of gastrocnemius, tibialis anterior, and soleus muscles. TE supplementation significantly improved body weight loss and tibialis anterior weight in P8 mice, with no difference in food intake between groups. Transcriptomic analysis revealed that TE significantly downregulated klf15 in gastrocnemius, redd1 in soleus and tibialis anterior, and foxo1 in soleus compared to unsupplemented P8 mice.

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preclinical research

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ORIGINAL PAPER

PMC10141758

Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice

Life

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ABSTRACT

Abstract Muscle atrophy is one of the main causes of sarcopenia—the age-related loss of skeletal muscle. In this study, we investigated the effect of turmeric ( Curcuma longa ) extract (TE) supplementation on age-related muscle atrophy in a senescence-accelerated mouse model and explored the underlying mechanisms. Twenty-six-week-old male, senescence-accelerated mouse resistant (SAMR) mice received the AIN-93G basal diet, while twenty-six-week-old male, senescence-accelerated mouse prone 8 (SAMP8) mice received the AIN-93G basal diet or a 2% TE powder-supplemented diet for ten weeks. Our findings revealed that TE supplementation showed certain effects on ameliorating the decrease in body weight, tibialis anterior weight, and mesenteric fat tissue weight in SAMP8 mice. TE improved gene expression in the glucocorticoid receptor-FoxO signaling pathway in skeletal muscle, including redd1 , klf15 , foxo1 , murf1 , and mafbx . Furthermore, TE might have the certain potential on improving the dynamic balance between anabolic and catabolic processes by inhibiting the binding of glucocorticoid receptor or FoxO1 to the glucocorticoid response element or FoxO-binding element in the MuRF1 promoter in skeletal muscle, thereby promoting muscle mass and strength, and preventing muscle atrophy and sarcopenia prevention. Moreover, TE may have reduced mitochondrial damage and maintained cell growth and division by downregulating the mRNA expression of the genes mfn2 and tsc2 . Thus, the results indicated TE’s potential for preventing age-related muscle atrophy and sarcopenia. Keywords: turmeric extract, age-related skeletal muscle atrophy, sarcopenia, senescence-accelerated mouse model, GR-FoxO signaling pathway

CITATION EXPORT

Weida Lyu, Marika Kousaka, Huijuan Jia et al.. Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice. Life. (2023). https://doi.org/10.3390/life13040941

AUTHORS

4 · 2 CENTRES

Weida Lyu, Marika Kousaka, Huijuan Jia, Hisanori Kato

1Health Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0032, Japan
2Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0032, Japan