Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive

Journal of Cosmetic Dermatology · 4 authors, 4 centres

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TL;DR

This half-face clinical study compared a new polyhydroxy acid (PHA) peel serum to mandelic acid and a placebo in 30 women with sensitive skin. The PHA serum significantly improved skin roughness, wrinkle breadth, firmness, and elasticity over 8 weeks, and was well tolerated.

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Efficacy was measured using noninvasive bioengineering techniques for moisturization, viscoelasticity, smoothness, wrinkles, and stratum corneum renewal. The PHA serum was well tolerated and produced a significant decrease in skin roughness and wrinkle breadth, and an improvement in firmness and elasticity compared to both mandelic acid and placebo. Specifically, the PHA serum led to a significant improvement in stratum corneum cohesion of 23.54% at 4 weeks.

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cohort

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dermatology

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ORIGINAL PAPER

PMC10087944

Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive

Journal of Cosmetic Dermatology

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ABSTRACT

Abstract Background Actually, the use of chemical peels in cosmetics and dermatology continues to grow due to their versatility, clinical endpoint–directed predictability, and favorable risk profile in comparison to lasers. The chemical peel is a generally safe method for treatment of some skin disorders and to refresh and rejuvenate the skin. The major challenge of chemical peels is the tolerability, that is because of sensitive skin which is one of the most common skin disorders. Aim The aim of this study was to evaluate the effectiveness of the new Miamo Renewal Peel Serum formulated with a pool of new generation acids (ELPA25™) on sensitive skin with respect to mandelic acid serum only and with respect to placebo comparison. Materials and Methods The “in vivo” study following the half‐face experimental protocol active versus placebo involved 30 healthy Caucasian female volunteers between 25 and 64 years, with sensitive skin, who were divided into two different groups. ELPA25™ serum was applied in one group three times a week for 8 weeks. The other group, with the same protocol, applied an active serum containing mandelic acid, as control, versus placebo. In particular, skin moisturizing, skin viscoelastic properties, skin surface smoothness, wrinkle reduction, and stratum corneum renewal were evaluated. Results Renewal Peel Serum was very well tolerated from sensitive skin. A significant decrease in skin roughness and wrinkle breadth, and an improvement in firmness and in skin elasticity, was observed after 2 months of treatment with respect both to mandelic acid serum and to placebo comparison. Conclusions Scientific protocol using self‐controlled study methodology and noninvasive skin bioengineering techniques with adequate statistical methods were able to evaluate both the safety and the efficacy of the new Miamo Renewal Peel Serum. This study highlighted that the Miamo Renewal Peel Serum formulated with a patent‐pending mixture of new generation acids (ELPA25™) exerts many beneficial effects and it can be successfully employed for sensitive skin.

CITATION EXPORT

Giulia Gentili, Paola Perugini, Stefano Bugliaro et al.. Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive. Journal of Cosmetic Dermatology. (2022). https://doi.org/10.1111/jocd.15215

AUTHORS

4 · 4 CENTRES

Giulia Gentili, Paola Perugini, Stefano Bugliaro, Camilla D'Antonio

1 Scientific Department Medspa Milano Italy
2 Department of Drug Sciences University of Pavia Pavia Italy
3 Etichub, Academic spin‐off University of Pavia Pavia Italy
4 Coslab Tecnologia Cosmetica Brescia Italy