SEARCHSYSTEMATIC_REVIEWoncology, obstetrics and gynecology

systematic_review·oncology, obstetrics and gynecology, systematic review, clinical trial·PMC10191940

Efficacy of exercise interventions for women during and after gynaecological cancer treatment – a systematic scoping review

Supportive Care in Cancer · 9 authors, 9 centres

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FIDELITY 100%

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This systematic scoping review analyzed 11 exercise intervention studies in women during or after gynaecological cancer treatment. It found consistent evidence of improvement in exercise capacity, muscular strength, and agility, but inconsistent effects on quality of life and body composition.

Full summary

797 CHARS

Studies were qualitatively appraised and synthesized. Most interventions occurred post-treatment, were combined or aerobic, and were unsupervised. Overall, 33 outcomes were assessed, with improvements reported in aerobic capacity (e.g., V̇O₂ Peak +1.6 mL/kg/min), lower-limb strength (e.g., 30-second sit-to-stand +2-4 repetitions), upper-limb strength, and agility. Changes in quality of life, anthropometry, balance, and flexibility were inconsistent. Limitations included moderate-to-high risk of bias, heterogeneous study designs, and small sample sizes (median 35), which may explain inconsistent findings for some outcomes. The evidence suggests exercise can improve physical function, which typically declines after cancer, but larger trials are needed to confirm effects on other outcomes.

STUDY TYPE

systematic_review

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10191940

Efficacy of exercise interventions for women during and after gynaecological cancer treatment – a systematic scoping review

Supportive Care in Cancer

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ABSTRACT

Abstract Purpose To systematically synthesise evidence of exercise intervention efficacy for physical/psychosocial outcomes that matter to women during/following treatment for gynaecological cancer. Methods Five databases were searched (PubMed, EMBASE, CINAHL, PsychInfo, Scopus). Exercise-only intervention studies that included women during/ following treatment for any gynaecological cancer, with/ without control comparison, on any physical or psychosocial outcome(s), were included and qualitatively appraised using the Revised Cochrane Risk of Bias tool and a modified Newcastle-Ottawa Scale. Results Seven randomised controlled trials (RCTs), three single-arm pre-post studies, and one prospective cohort study satisfied were included (11 studies). Most studies were completed following treatment (91%), included combined (aerobic and resistance; 36%) and aerobic (36%) training, were fully/mostly (63%) unsupervised, and had a moderate-to-high risk of bias. Overall, 33 outcomes (64% objectively-measured) were assessed. Improvements were observed in aerobic capacity (V̇O 2 Peak +1.6 mL/kg/min, 6-minute walk distance +20-27 m), lower- (30-second sit-to-stand +2-4 repetitions) and upper-limb strength (30-second arm curl +5 repetitions; 1RM grip strength/chest press +2.4-3.1 kg), and agility (timed up-and-go -0.6 seconds). However, changes in quality of life, anthropometry/body composition, balance and flexibility were inconsistent. There was no evidence to support worsening of outcomes. Conclusion Preliminary research into the role of exercise post-gynaecological cancer suggests an improvement in exercise capacity, muscular strength, and agility which, in the absence of exercise, typically decline following gynaecological cancer. Future exercise trials involving larger and more diverse gynaecological cancer samples will improve understanding of the potential and magnitude of effect of guideline-recommended exercise on outcomes that matter to patients. Supplementary Information The online version contains supplementary material available at 10.1007/s00520-023-07790-8. Keywords: fitness, strength, body composition, oncology, agility

CITATION EXPORT

Grace Laura Rose, Elizabeth Mary Stewart, Briana Kristine Clifford et al.. Efficacy of exercise interventions for women during and after gynaecological cancer treatment – a systematic scoping review. Supportive Care in Cancer. (2023). https://doi.org/10.1007/s00520-023-07790-8

AUTHORS

9 · 9 CENTRES

Grace Laura Rose, Elizabeth Mary Stewart, Briana Kristine Clifford, Tom George Bailey, Alexandra Jane Rush, Claudia Rose Abbott, Sandra Christine Hayes, Andreas Obermair, Alexandra Leigh McCarthy

1School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia
2School of Health, University of the Sunshine Coast, Sippy Downs, Australia
3School of Nursing, Midwifery and Social Work, The University of Queensland, Brisbane, Australia
4School of Health Sciences, University of New South Wales, Sydney, Australia
5School of Health Sciences and Social Work, Griffith University, Brisbane, Australia
6Menzies Health Institute Queensland, Griffith University, Brisbane, Australia
7School of Medicine, The University of Queensland, Brisbane, Australia
8Queensland Centre for Gynaecological Cancer, Royal Brisbane and Women’s Hospital, Brisbane, Australia
9Mater Research Institute, Brisbane, Australia