Electroretinography and suicidal behaviors: a systematic review

This systematic review followed PRISMA guidelines and searched multiple databases for studies reporting ERG findings in individuals with suicidal behaviors. Most included studies were case reports and case series. The review found that a-wave amplitude and implicit time were generally normal, while a-wave latency was decreased compared to controls. The review's principal limitations include the predominance of case reports lacking statistical power, the absence of studies linking retinal neurotransmitter changes to specific brain regions involved in suicidal behavior, cross-sectional designs with small samples precluding causal inference, and variability in timing of ERG assessment after suicidal attempts.