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TL;DR
This narrative review summarizes bioprocess conditions and optimization methods for the industrial-scale production of Bacillus endospores, used in probiotics and biopesticides.
Engineering in Life Sciences · 2 authors, 1 centre
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This narrative review summarizes bioprocess conditions and optimization methods for the industrial-scale production of Bacillus endospores, used in probiotics and biopesticides.
This narrative review synthesizes literature from the last 20 years on bioprocess development for producing Bacillus spp. endospores. The review emphasizes that sporulation is triggered by nutrient depletion and requires high cell density, and that optimal parameters are highly strain-specific. For example, pH control can improve sporulation efficiency in some strains but has no effect in others. The implications guide industrial bioprocess development for probiotics and biopesticides, highlighting the need for strain-specific optimization.