SEARCHNARRATIVE_REVIEWneurology, preclinical research

narrative_review·neurology, preclinical research, biomedical research·PMC10193753

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Current Neuropharmacology · 3 authors, 2 centres

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The evidence base is primarily mechanistic and preclinical, with human relevance being indirect as it is based on clinical observations of glucose hypometabolism preceding symptoms.

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The evidence base is primarily mechanistic and preclinical, with human relevance being indirect as it is based on clinical observations of glucose hypometabolism preceding symptoms.

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narrative_review

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neurology

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AI pipeline

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ORIGINAL PAPER

PMC10193753

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Current Neuropharmacology

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ABSTRACT

Abstract Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. The occult nature of the onset and the uncertainty of the etiology largely impede the development of therapeutic strategies for AD. Previous studies revealed that the disorder of energy metabolism in the brains of AD patients appears far earlier than the typical pathological features of AD, suggesting a tight association between energy crisis and the onset of AD. Energy crisis in the brain is known to be induced by the reductions in glucose uptake and utilization, which may be ascribed to the diminished expressions of cerebral glucose transporters (GLUTs), insulin resistance, mitochondrial dysfunctions, and lactate dysmetabolism. Notably, the energy sensors such as peroxisome proliferators-activated receptor (PPAR), transcription factor EB (TFEB), and AMP-activated protein kinase (AMPK) were shown to be the critical regulators of autophagy, which play important roles in regulating beta-amyloid (Aβ) metabolism, tau phosphorylation, neuroinflammation, iron dynamics, as well as ferroptosis. In this study, we summarized the current knowledge on the molecular mechanisms involved in the energy dysmetabolism of AD and discussed the interplays existing between energy crisis, autophagy, and ferroptosis. In addition, we highlighted the potential network in which autophagy may serve as a bridge between energy crisis and ferroptosis in the progression of AD. A deeper understanding of the relationship between energy dysmetabolism and AD may provide new insight into developing strategies for treating AD; meanwhile, the energy crisis in the progression of AD should gain more attention. Keywords: Alzheimer’s disease, energy crisis, autophagy, ferroptosis, iron metabolism, beta-amyloid, tau protein

CITATION EXPORT

Da-Long He, Yong-Gang Fan, Zhan-You Wang. Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues. Current Neuropharmacology. (2023). https://doi.org/10.2174/1570159X20666220817140737

AUTHORS

3 · 2 CENTRES

Da-Long He, Yong-Gang Fan, Zhan-You Wang

1Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang, 110122, China;
2Key Laboratory of Medical Cell Biology of Ministry of Education, Health Sciences Institute of China Medical University, Shenyang, 110122, China