European Journal of Pediatrics · 7 authors, 7 centres
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This observational study evaluated ceftriaxone pharmacokinetics in 24 critically ill Egyptian pediatric patients. The current dosing regimen (50 to 100 mg/kg) provided adequate drug exposure, but mild increases in liver enzymes and bilirubin were noted, suggesting monitoring is needed.
This observational cohort study evaluated the pharmacokinetics and clinical safety of ceftriaxone in 24 critically ill Egyptian pediatric patients. Total and free drug concentrations were best described by a one-compartment model. The results showed that the standard dosing regimen (50 to 100 mg/kg) achieved trough concentrations above the target range for susceptible organisms in all patients. Patients with hypoalbuminemia or impaired renal function exhibited elevated free fractions and altered volume of distribution. A mild, significant increase in total bilirubin and liver enzymes (ALT, AST) was observed post-treatment, though no gallbladder stones developed. Covariate analysis indicated body weight significantly affected clearance. Limitations include the small sample size and ethical constraints on sampling times. The findings support the current dosing regimen for adequate exposure but highlight the need for liver function monitoring.
