Diagnostics · 5 authors, 3 centres
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In a cross-sectional study of 30 gout patients and 32 healthy controls, higher serum uric acid levels were independently associated with decreased superficial capillary plexus density and increased choriocapillary flow deficit on OCT-A imaging. These microvascular changes were more pronounced in women than in men.
The superficial foveal and perifoveal vessel densities were significantly lower in the gout group (p = 0.014 and p = 0.045, respectively). The choriocapillaris flow zone was also significantly lower in the patient group (p = 0.008). The foveal avascular zone area, perimeter, and 300-degree peripheral zone differed significantly between groups (p = 0.000, p = 0.011, and p = 0.024, respectively). A higher serum uric acid level was independently associated with decreased superficial capillary plexus density and increased choriocapillary flow deficit, with men showing less sensitivity to elevated uric acid than women. No significant differences were found in deep capillary plexus densities or retinal nerve fiber layer thickness between groups.
