SEARCHNARRATIVE_REVIEWoncology, epidemiology

narrative_review·oncology, epidemiology, public health, gastroenterology·PMC10099575

Exercise‐induced changes to the human gut microbiota and implications for colorectal cancer: a narrative review

The Journal of Physiology · 5 authors, 5 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review synthesizes existing research on how exercise can modify the gut microbiota and discusses how these changes may theoretically reduce colorectal cancer risk by creating a microbial profile opposite to that associated with the disease.

Full summary

526 CHARS

This narrative review synthesizes research from two parallel fields: the effects of exercise on the gut microbiota and the role of the gut microbiota in colorectal cancer (CRC). The review highlights that much of the current evidence is preliminary and observational, with limitations including high heterogeneity in microbiome analysis methods and exercise prescriptions across studies. The authors note that future mechanistic studies are needed to confirm the physiological pathways and determine optimal exercise regimens.

STUDY TYPE

narrative_review

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10099575

Exercise‐induced changes to the human gut microbiota and implications for colorectal cancer: a narrative review

The Journal of Physiology

READ THE FULL PAPER

ABSTRACT

Abstract Physical activity is associated with reduced risks of colorectal cancer (CRC) incidence, recurrence and mortality. While these findings are consistent, the mechanism/s underlying this association remain unclear. Growing evidence supports the many ways in which differing characteristics of the gut microbiota can be tumourigenic or protective against CRC. CRC is characterised by significant dysbiosis including reduced short chain fatty acid‐producing bacteria. Recent findings suggest that exercise can modify the gut microbiota, and these changes are inverse to the changes seen with CRC; however, this exercise‐microbiota interaction is currently understudied in CRC. This review summarises parallel areas of research that are rapidly developing: The exercise–gut microbiota research and cancer–gut microbiota research and highlights the salient similarities. Preliminary evidence suggests that these areas are linked, with exercise mediating changes that promote the antitumorigenic characteristics of the gut microbiota. Future mechanistic and population‐specific studies are warranted to confirm the physiological mechanism/s by which exercise changes the gut microbiota, and the influence of the exercise–gut interaction on cancer specific outcomes in CRC.

CITATION EXPORT

Alexander N. Boytar, Marloes Dekker Nitert, Mark Morrision et al.. Exercise‐induced changes to the human gut microbiota and implications for colorectal cancer: a narrative review. The Journal of Physiology. (2022). https://doi.org/10.1113/JP283702

AUTHORS

5 · 5 CENTRES

Alexander N. Boytar, Marloes Dekker Nitert, Mark Morrision, Tina L. Skinner, David G. Jenkins

1 School of Human Movement and Nutrition Sciences The University of Queensland Brisbane Australia
2 School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Australia
3 The University of Queensland Diamantina Institute Faculty of Medicine Translational Research Institute The University of Queensland Brisbane Australia
4 University of the Sunshine Coast Maroochydore Australia
5 Applied Sports Science Technology and Medicine Research Centre Swansea University Wales UK