Existence of Quantum Pharmacology in Sartans: Evidence in Isolated Rabbit Iliac Arteries

International Journal of Molecular Sciences · 9 authors, 7 centres

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TL;DR

The central result was that both commercial and novel ARBs significantly inhibited contraction responses to vasopressors at ultra-high dilutions, and one novel ARB lowered mean arterial pressure in conscious rabbits.

Full summary

441 CHARS

The study employed ex vivo isolated rabbit iliac artery rings to assess vascular contraction responses to angiotensin A, angiotensin II, and phenylephrine in the presence of commercial ARBs (candesartan, telmisartan), novel imidazole-based bisartans (ACC519T, ACC519T(2), BV6(K^+^)2), and nirmatrelvir at ultra-high dilutions. In vivo, a low dose of ACC519T produced a dose-dependent reduction in mean arterial pressure in conscious rabbits.

STUDY TYPE

other

SPECIALTY

cardiology

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100% · A

ORIGINAL PAPER

PMC10744031

Existence of Quantum Pharmacology in Sartans: Evidence in Isolated Rabbit Iliac Arteries

International Journal of Molecular Sciences

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ABSTRACT

Quantum pharmacology introduces theoretical models to describe the possibility of ultra-high dilutions to produce biological effects, which may help to explain the placebo effect observed in hypertensive clinical trials. To determine this within physiology and to evaluate novel ARBs, we tested the ability of known angiotensin II receptor blockers (ARBs) (candesartan and telmisartan) used to treat hypertension and other cardiovascular diseases, as well as novel ARBs (benzimidazole- N -biphenyl tetrazole (ACC519T), benzimidazole- bis - N , N ′-biphenyl tetrazole (ACC519T(2)) and 4-butyl-N,N0-bis[[20-2Htetrazol-5-yl)biphenyl-4-yl]methyl)imidazolium bromide (BV6(K + ) 2 ), and nirmatrelvir (the active ingredient in Paxlovid) to modulate vascular contraction in iliac rings from healthy male New Zealand White rabbits in responses to various vasopressors (angiotensin A, angiotensin II and phenylephrine). Additionally, the hemodynamic effect of ACC519T and telmisartan on mean arterial pressure in conscious rabbits was determined, while the ex vivo ability of BV6(K + ) 2 to activate angiotensin-converting enzyme-2 (ACE2) was also investigated. We show that commercially available and novel ARBs can modulate contraction responses at ultra-high dilutions to different vasopressors. ACC519T produced a dose-dependent reduction in rabbit mean arterial pressure while BV6(K + ) 2 significantly increased ACE2 metabolism. The ability of ARBs to inhibit contraction responses even at ultra-low concentrations provides evidence of the existence of quantum pharmacology. Furthermore, the ability of ACC519T and BV6(K + ) 2 to modulate blood pressure and ACE2 activity, respectively, indicates their therapeutic potential against hypertension.

CITATION EXPORT

Laura Kate Gadanec, Jordan Swiderski, Vasso Apostolopoulos et al.. Existence of Quantum Pharmacology in Sartans: Evidence in Isolated Rabbit Iliac Arteries. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms242417559

AUTHORS

9 · 7 CENTRES

Laura Kate Gadanec, Jordan Swiderski, Vasso Apostolopoulos, Kostantinos Kelaidonis, Veroniki P. Vidali, Aleksander Canko, Graham J. Moore, John M. Matsoukas, Anthony Zulli

1Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia; [email protected] (L.K.G.); [email protected] (J.S.); [email protected] (V.A.)
2Immunology Program, Australian Institute for Musculoskeletal Science (AIMSS), Melbourne, VIC 3021, Australia
3NewDrug PC, Patras Science Park, 26 504 Patras, Greece; [email protected]
4Institute of Nanoscience and Nanotechnology, National Centre for Scientific Research “Demokritos”, Ag. Paraskevi, 153 41 Athens, Greece; [email protected] (V.P.V.); [email protected] (A.C.)
5Pepmetics Inc., 772 Murphy Place, Victoria, BC V6Y 3H4, Canada; [email protected]
6Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
7Department of Chemistry, University of Patras, 265 04 Patras, Greece

EDITOR / REVIEWER

Peter Illes