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TL;DR
The central result was that NTX treatment partially reversed BDL-induced increases in bone THBS1 levels and decreased bone NO levels.
Scientific Reports · 6 authors, 4 centres
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The central result was that NTX treatment partially reversed BDL-induced increases in bone THBS1 levels and decreased bone NO levels.
The study investigated the effects of naltrexone (NTX) on the thrombospondin-1 (THBS1)/endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway in a rat model of hepatic osteodystrophy. Bile duct ligation (BDL) was used to induce liver cirrhosis and associated osteoporosis. NTX was administered to BDL rats. NTX treatment significantly reduced hepatic collagen and increased bone NO levels. However, NTX did not produce a statistically significant improvement in bone histomorphometric parameters (tibial cortical thickness/area, trabecular thickness/number), though it showed a partial, non-significant positive effect. eNOS mRNA expression was comparable across groups. The authors conclude NTX may have positive effects on bone at the molecular level by modulating the THBS1/NO axis, but note that longer treatment periods may be needed to observe structural changes.