Toxics · 8 authors, 4 centres
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This case-control study compared serum metal levels in 232 women with unexplained recurrent miscarriage (uRM) and 43 healthy controls. The central result was that higher serum levels of lead and vanadium, and lower levels of calcium and selenium, were associated with increased risk of uRM after adjusting for confounders.
This study was a case-control investigation comparing serum metal levels between 232 women with unexplained recurrent miscarriage (uRM) and 43 healthy controls. 22 elements were measured via inductively coupled plasma–mass spectrometry. Specifically, controls had higher calcium (104.37 mg/L vs. 92.65 mg/L) and selenium (131.85 µg/L vs. 117.80 µg/L) than the total uRM group, while vanadium (0.15 µg/L vs. 0.23 µg/L) and lead (0.01 µg/L vs. 0.28 µg/L) were lower in controls. The study also found differing correlation patterns between metals in the control versus uRM groups. The implications are that assessing serum metal levels may help identify risks for uRM, but larger prospective studies are needed to confirm these associations and explore underlying mechanisms.
