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TL;DR
This is a case report of a 41-year-old male with progressive facial numbness, eyelid closure weakness, slurred speech, and dysphagia over 6 years, leading to a diagnosis of FOSMN.
Medicine · 7 authors, 2 centres
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This is a case report of a 41-year-old male with progressive facial numbness, eyelid closure weakness, slurred speech, and dysphagia over 6 years, leading to a diagnosis of FOSMN.
This is a case report of a 41-year-old male with progressive facial numbness, eyelid closure weakness, slurred speech, and dysphagia over 6 years, leading to a diagnosis of FOSMN. Testing also revealed positive anti-AchR and anti-titin antibodies, a positive neostigmine test, and abnormal repetitive nerve stimulation, indicating comorbid MG. Treatment with pyridostigmine bromide and prednisolone led to improvement in symptoms for at least 4 months. The authors note that FOSMN is often considered neurodegenerative, while MG is autoimmune. The report highlights this rare co-occurrence and suggests a possible immune-mediated pathogenesis, though evidence is limited to this single case.