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TL;DR
This systematic review and meta-analysis of 27 observational studies found that a positive family history of colorectal cancer (CRC) or any cancer was significantly associated with an increased risk of developing CRC in the EMRO region.
Scientific Reports · 12 authors, 5 centres
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This systematic review and meta-analysis of 27 observational studies found that a positive family history of colorectal cancer (CRC) or any cancer was significantly associated with an increased risk of developing CRC in the EMRO region.
This study was a systematic review and meta-analysis of 27 observational studies evaluating the association between a positive family history of cancer and the risk of colorectal cancer (CRC) in countries of the Eastern Mediterranean Region Office (EMRO). The meta-analysis found a significant association between a family history of CRC and CRC risk (OR 2.21; 95% CI 1.54–3.17), as well as between a family history of any cancer and CRC risk (OR 1.76; 95% CI 1.27–2.42). Subgroup analyses indicated that a first-degree family history of CRC was associated with a more than twofold increased risk. Meta-regression showed that larger sample size significantly influenced the association for family history of CRC. Limitations included high heterogeneity, potential publication bias, and a lack of data on second- or third-degree relatives or specific cancer types in family members. The findings underscore the importance of screening for individuals with a family history of cancer in this region.