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other·preclinical research, biomedical research, antioxidants, nutrition, micronutrients·PMC10045799

Fe (III)-Mediated Antioxidant Response of the Acidotolerant Microalga Coccomyxa onubensis

Antioxidants · 8 authors, 3 centres

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The authors measured changes in growth, photosynthetic viability, and the levels of antioxidant biomarkers.

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The authors measured changes in growth, photosynthetic viability, and the levels of antioxidant biomarkers. The central results indicate that moderate Fe (III) levels improved growth and photosynthetic viability. Additionally, Fe (III) induced oxidative stress, which the microalga countered by increasing intracellular levels of the enzyme superoxide dismutase (SOD) and flavonoids, while the content of other phenolic molecules and polyunsaturated fatty acids (PUFAs) decreased. The authors suggest the decrease in phenolics and PUFAs may be due to their involvement in reactive oxygen species (ROS) scavenging. The study concludes that this antioxidant capacity allows the use of moderate Fe (III) to trigger the accumulation of valuable antioxidant molecules for potential anti-inflammatory applications.

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other

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preclinical research

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ORIGINAL PAPER

PMC10045799

Fe (III)-Mediated Antioxidant Response of the Acidotolerant Microalga Coccomyxa onubensis

Antioxidants

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ABSTRACT

Coccomyxa onubensis ( C. onubensis ) is an acidotolerant microalga isolated from Tinto River (Huelva), which contains high levels of metal cations in solution, mainly Fe (II) and (III), and Cu (II). Fe is more bioavailable at low pH, mainly because Fe (II) and Fe (III) are far more soluble, especially Fe (III). For this reason, this study aims to evaluate both physiological and biochemical responses of C. onubensis when subjected to Fe (III)-induced stress. Changes in growth, photosynthetic viability and antioxidant responses to the induced oxidative stress were determined. The results obtained suggest that the addition of moderate Fe (III) levels to C. onubensis cultures results in improved growth and photosynthetic viability. Increases in the intracellular levels of the enzyme superoxide dismutase (SOD) and flavonoids, used as antioxidant response biomarkers, a point at Fe (III)-mediated oxidative stress induction. The apparent decrease in the content of other phenolic molecules and polyunsaturated fatty acids might be understood as a sign of antioxidant molecules' involvement in reactive oxygen species (ROS) scavenging. In conclusion, a noticeable antioxidant capacity displayed by C. onubensis allows the use of moderate Fe (III) levels to trigger the accumulation of valuable antioxidant molecules, allowing the production of cell extracts with potential anti-inflammatory activity.

CITATION EXPORT

María Robles, Rafael Torronteras, Carol Ostojic et al.. Fe (III)-Mediated Antioxidant Response of the Acidotolerant Microalga Coccomyxa onubensis. Antioxidants. (2023). https://doi.org/10.3390/antiox12030610

AUTHORS

8 · 3 CENTRES

María Robles, Rafael Torronteras, Carol Ostojic, Cinta Oria, María Cuaresma, Inés Garbayo, Francisco Navarro, Carlos Vílchez

1Algal Biotechnology, CIDERTA-RENSMA, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain
2Biology and Environmental Analysis, RENSMA, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain
3Cell Alterations by Exogenous Agents, RENSMA, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain

EDITOR / REVIEWER

Félix López De Felipe