Cancer Medicine · 10 authors, 8 centres
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This 8-week non-randomised feasibility pilot trial evaluated a thrice-weekly telehealth-supervised multimodal exercise programme in 11 patients with advanced melanoma receiving checkpoint inhibitor therapy. The intervention met four of five feasibility criteria, caused no severe or life-threatening adverse events, significantly improved physical function, and maintained quality of life.
This single-arm feasibility pilot trial enrolled 11 patients with advanced melanoma receiving checkpoint inhibitor therapy in an 8-week telehealth-delivered multimodal exercise programme performed thrice weekly, with baseline and post-intervention assessments. The study met feasibility criteria on four of five pre-determined measures: completion rate 91%, programme attendance 88%, median resistance exercise compliance 82.1%, aerobic exercise compliance 84.9%, and tolerance 88%, though the recruitment rate of 48% fell just below the 50% threshold. Two participants experienced a transient ischaemic attack, neither during exercise. Physical function measures significantly improved, and quality of life was maintained following the intervention. These preliminary findings suggest telehealth exercise may be feasible and safe for this population but require confirmation in larger randomised controlled trials.
