SEARCHCOHORTophthalmology, cataract surgery

cohort·ophthalmology, cataract surgery, nutrition, epidemiology, public health·PMC10564725

Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank study

Eye · 8 authors, 4 centres

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TL;DR

This prospective cohort study of 72,160 UK Biobank participants found that higher fruit and vegetable intake over a mean 9.1-year follow-up was associated with a lower risk of developing cataract.

Full summary

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This prospective cohort study analyzed data from 72,160 UK Biobank participants who were free of cataract at baseline. Subgroup analyses suggested smokers and men might benefit more.

STUDY TYPE

cohort

SPECIALTY

ophthalmology

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100% · A

ORIGINAL PAPER

PMC10564725

Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank study

Eye

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ABSTRACT

Purpose: A prospective cohort study to investigate the association between fruit and vegetable (F&V) intake and the risk of cataract. Methods: We included 72,160 participants who were free of cataract at baseline from the UK Biobank. Frequency and type of F&V intake were assessed using a web-based 24 h dietary questionnaire from 2009 to 2012. Development of cataract during the follow-up was defined by self-report or hospital inpatient records up to 2021. Cox proportional regression models were used to estimate the association between F&V intake and incident cataract. Results: During a mean follow-up of 9.1 years, 5753 participants developed cataract with a corresponding incidence of 8.0%. After adjusting for multiple demographic, medical and lifestyle covariates, higher intake of F&V were associated with a lower risk of cataract (≥6.5 vs. <2 servings/week: hazards ratio [HR]: 0.82, 95% CI: 0.76 to 0.89; P < 0.0001). Regarding specific types, significant reduced risk of cataract was found for higher intake of legumes ( P = 0.0016), tomatoes (≥5.2 vs. <1.8 servings/week: HR: 0.94, 95% CI: 0.88 to 1.00), and apple and pear (>7 vs. <3.5 servings/week: 0.89, 95% CI: 0.83 to 0.94; P < 0.0001), but not for cruciferous vegetables, green leafy vegetables, berry, citrus fruit or melon. Smokers were found to benefit more from F&V intake than former and never smokers. Men also could benefit more from higher vegetable intake than women. Conclusions: More F&V intake, especially legumes, tomatoes, apple, and pear, was associated with a lower risk of cataract in this UK Biobank cohort.

CITATION EXPORT

Huiya Fan, Xiaotong Han, Xianwen Shang et al.. Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank study. Eye. (2023). https://doi.org/10.1038/s41433-023-02498-9

AUTHORS

8 · 4 CENTRES

Huiya Fan, Xiaotong Han, Xianwen Shang, Zhuoting Zhu, Mingguang He, Guihua Xu, Zilin Chen, Ruidong Deng

1https://ror.org/04bwajd86grid.470066.30000 0005 0266 1344Department of Ophthalmology, Huizhou Central People’s Hospital, Huizhou, China
2https://ror.org/0064kty71grid.12981.330000 0001 2360 039XState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China
3grid.410670.40000 0004 0625 8539Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC Australia
4https://ror.org/01ej9dk98grid.1008.90000 0001 2179 088XOphthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC Australia