SEARCHOTHERcardiology, preclinical research

other·cardiology, preclinical research, biomedical research, research methods·PMC10452209

Functional Cardiovascular Characterization of the Common Marmoset ( Callithrix jacchus )

Biology · 10 authors, 7 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

All three techniques were suitable for assessing cardiac function, each with distinct advantages and disadvantages.

Full summary

838 CHARS

This preclinical study aimed to provide a functional cardiovascular characterization of the common marmoset by comparing three assessment methods. Researchers performed invasive intracardiac pressure–volume loop (PV loop) measurements in seven animals, magnetic resonance imaging (MRI) in six, and echocardiography in five young adult male marmosets. The central results show that all three modalities were suitable for characterizing cardiac function, though with some systemic variations. The discussion notes that echocardiography and MRI are non-invasive and allow for serial measurements, while PV loop measurements provide comprehensive, load-independent parameters in real-time. The findings support the use of the common marmoset as a primate model for cardiovascular disease research and provide baseline data for future studies.

STUDY TYPE

other

SPECIALTY

cardiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10452209

Functional Cardiovascular Characterization of the Common Marmoset ( Callithrix jacchus )

Biology

READ THE FULL PAPER

ABSTRACT

Abstract Simple Summary Animal models reflecting the human situation as accurately as possible are still essential to develop new therapies for diseases such as heart failure. The common marmoset ( Callithrix jacchus ), a commonly used small non-human primate, resembles humans in a variety of aspects. However, its cardiovascular system has not yet been sufficiently studied. It is imperative, though, to have a full understanding of this animal’s cardiovascular system and to have tools to accurately survey it. Therefore, for the first time, cardiac catheterizations along with intracardiac pressure–volume loop (PV loop) measurements were performed that provide real-time heart function data. By developing a protocol for cardiac catheterization (PV loop) in this animal species, the cardiac function in young, healthy animals was assessed. In the same animals, the obtained results were compared with generally established methods, namely, magnetic resonance imaging (MRI) and echocardiography. All three methods were suitable to describe cardiac function in the common marmoset; however, a comparison of the results revealed certain differences between the three techniques that are important for future research. Depending on the study objective, each method has its advantages and disadvantages and should, therefore, be carefully selected. The results provide the basis to establish the common marmoset as a promising primate model for cardiovascular disease. Abstract Appropriate cardiovascular animal models are urgently needed to investigate genetic, molecular, and therapeutic approaches, yet the translation of results from the currently used species is difficult due to their genetic distance as well as their anatomical or physiological differences. Animal species that are closer to the human situation might help to bridge this translational gap. The common marmoset ( Callithrix jacchus ) is an interesting candidate to investigate certain heart diseases and cardiovascular comorbidities, yet a basic functional characterization of its hemodynamic system is still missing. Therefore, cardiac functional analyses were performed by utilizing the invasive intracardiac pressure–volume loops (PV loop) system in seven animals, magnetic resonance imaging (MRI) in six animals, and echocardiography in five young adult male common marmosets. For a direct comparison between the three methods, only data from animals for which all three datasets could be acquired were selected. All three modalities were suitable for characterizing cardiac function, though with some systemic variations. In addition, vena cava occlusions were performed to investigate the load-independent parameters collected with the PV loop system, which allowed for a deeper analysis of the cardiac function and for a more sensitive detection of the alterations in a disease state, such as heart failure or certain cardiovascular comorbidities. Keywords: hemodynamic measurement, common marmoset, Callithrix jacchus , magnetic resonance imaging, echocardiography, animal model, cardiac, pressure–volume loops, heart failure

CITATION EXPORT

Lina Klösener, Sabine Samolovac, Ina Barnekow et al.. Functional Cardiovascular Characterization of the Common Marmoset (Callithrix jacchus). Biology. (2023). https://doi.org/10.3390/biology12081123

AUTHORS

10 · 7 CENTRES

Lina Klösener, Sabine Samolovac, Ina Barnekow, Jessica König, Amir Moussavi, Susann Boretius, Dieter Fuchs, Astrid Haegens, Rabea Hinkel, Matthias Mietsch

1Laboratory Animal Science Unit, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, [email protected] (M.M.)
2DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, 37075 Göttingen, Germany
3Institute for Animal Hygiene, Animal Welfare and Farm Animal Behavior, University of Veterinary Medicine, 30173 Hannover, Germany
4Functional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany
5Johann-Friedrich-Blumenbach Institute of Zoology and Anthropology, Georg August University, 37077 Göttingen, Germany
6FUJIFILM VisualSonics Inc., 1114 AB Amsterdam, The Netherlands
7Transonic Inc., Ithaca, NY 14850, USA