Functional differentiation of Sec13 paralogues in the euglenozoan protists

Open Biology · 6 authors, 7 centres

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This preclinical study used interactome proteomics and epitope-tagged localization in two euglenozoan protists to show that the ancient COPII component Sec13 has functionally diverged into two paralogues, Sec13a and Sec13b, with distinct cellular roles.

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This functional partition is supported by the presence of a nuclear localization signal in Sec13a but not Sec13b.

STUDY TYPE

other

SPECIALTY

preclinical research

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10264103

Functional differentiation of Sec13 paralogues in the euglenozoan protists

Open Biology

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ABSTRACT

Keywords: Diplonema , coatomer, membrane trafficking, nuclear pore complex, SEA/GATOR complex, paralogue expansion

CITATION EXPORT

Drahomíra Faktorová, Kristína Záhonová, Corinna Benz et al.. Functional differentiation of Sec13 paralogues in the euglenozoan protists. Open Biology. (2023). https://doi.org/10.1098/rsob.220364

AUTHORS

6 · 7 CENTRES

Drahomíra Faktorová, Kristína Záhonová, Corinna Benz, Joel B Dacks, Mark C Field, Julius Lukeš

1 Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic
2 Faculty of Sciences, University of South Bohemia, České Budějovice, Czech Republic
3 Faculty of Science, Charles University, BIOCEV, Vestec, Czech Republic
4 Life Science Research Centre, Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
5 Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
6 Centre for Life's Origins and Evolution, Department of Genetics, Evolution, and Environment, University College London, London, UK
7 School of Life Sciences, University of Dundee, Dundee, UK