Gastroesophageal reflux disease in children: What’s new right now?

World Journal of Gastrointestinal Endoscopy · 3 authors, 5 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review summarizes current knowledge on the pathogenesis, diagnosis, and management of gastroesophageal reflux disease (GERD) in children. It concludes that while diagnosis remains challenging, advances like combined pH-MII monitoring improve accuracy, and management should target underlying causes.

Full summary

215 CHARS

The review concludes that diagnosing GERD remains difficult and requires differentiation from physiological GER and other mimics, with management aiming to target the underlying aetiology and minimize complications.

STUDY TYPE

narrative_review

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10080553

Gastroesophageal reflux disease in children: What’s new right now?

World Journal of Gastrointestinal Endoscopy

READ THE FULL PAPER

ABSTRACT

Gastroesophageal reflux (GER) in children is very common and refers to the involuntary passage of gastric contents into the esophagus. This is often physiological and managed conservatively. In contrast, GER disease (GERD) is a less common pathologic process causing troublesome symptoms, which may need medical management. Apart from abnormal transient relaxations of the lower esophageal sphincter, other factors that play a role in the pathogenesis of GERD include defects in esophageal mucosal defense, impaired esophageal and gastric motility and clearance, as well as anatomical defects of the lower esophageal reflux barrier such as hiatal hernia. The clinical manifestations of GERD in young children are varied and nonspecific prompting the necessity for careful diagnostic evaluation. Management should be targeted to the underlying aetiopathogenesis and to limit complications of GERD. The following review focuses on up-to-date information regarding of the pathogenesis, diagnostic evaluation and management of GERD in children.

CITATION EXPORT

Palittiya Sintusek, Mohamed Mutalib, Nikhil Thapar. Gastroesophageal reflux disease in children: What’s new right now?. World Journal of Gastrointestinal Endoscopy. (2023). https://doi.org/10.4253/wjge.v15.i3.84

AUTHORS

3 · 5 CENTRES

Palittiya Sintusek, Mohamed Mutalib, Nikhil Thapar

Thai Pediatric Gastroenterology, Hepatology and Immunology Research Unit (TPGHAI), Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital and Thai Red Cross, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Bangkok, Thailand
Department of Paediatric Gastroenterology, Pediatric and Gastroenterology Services, Evelina London Children’s Hospital, London SE1 7EH, United Kingdom
Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, Brisbane, Queensland 4101, Australia
School of Medicine, University of Queensland, Brisbane, Queensland 4006, Australia
Woolworths Centre for Child Nutrition Research, Queensland University of Technology, Brisbane, Queensland 4101, Australia. [email protected]