International Journal of Molecular Sciences · 2 authors, 1 centre
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This narrative review describes molecular mechanisms—including gene mutations, novel enzymes, and gated calcium ion channels—that enable Mycobacterium tuberculosis to develop multidrug resistance. The authors argue that population displacement and migration may spread drug-resistant tuberculosis globally, necessitating international cooperation.
This narrative review examines molecular mechanisms underlying multidrug resistance in Mycobacterium tuberculosis, focusing on gene mutations, evolutionary development of new enzymes, and gated calcium ion channels. The review discusses how malnutrition, immunosuppression from fatigue and poor hygiene, and population displacement due to hostilities and natural catastrophes exacerbate tuberculosis spread, compounded by the COVID-19 pandemic. Implications are limited to identifying mechanisms and calling for international cooperation in healthcare, medication, food, and shelter to combat multidrug-resistant tuberculosis.
