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other·preclinical research, biomedical research, neurology, psychiatry, research methods·PMC10404230

Gene expression genetics of the striatum of Diversity Outbred mice

Scientific Data · 6 authors, 3 centres

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They created an interactive QTL viewer as a resource for the research community.

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They created an interactive QTL viewer as a resource for the research community. The study provides a foundational genetic resource for understanding molecular mechanisms in a brain region central to motivated behavior and addiction. The implications are primarily for future research into the genetic architecture of addiction-related traits in mice.

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other

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preclinical research

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ORIGINAL PAPER

PMC10404230

Gene expression genetics of the striatum of Diversity Outbred mice

Scientific Data

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ABSTRACT

Abstract Brain transcriptional variation is a heritable trait that mediates complex behaviors, including addiction. Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abundance. In this study, we profiled transcript abundance in the striatum of 386 Diversity Outbred (J:DO) mice of both sexes using RNA-Seq. All mice were characterized using a behavioral battery of widely-used exploratory and risk-taking assays prior to transcriptional profiling. We performed eQTL mapping, incorporated the results into a browser-based eQTL viewer, and deposited co-expression network members in GeneWeaver. The eQTL viewer allows researchers to query specific genes to obtain allelic effect plots, analyze SNP associations, assess gene expression correlations, and apply mediation analysis to evaluate whether the regulatory variant is acting through the expression of another gene. GeneWeaver allows multi-species comparison of gene sets using statistical and combinatorial tools. This data resource allows users to find genetic variants that regulate differentially expressed transcripts and place them in the context of other studies of striatal gene expression and function in addiction-related behavior. Subject terms: Behavioural genetics, Genetics of the nervous system

CITATION EXPORT

Vivek M Philip, Hao He, Michael C Saul et al.. Gene expression genetics of the striatum of Diversity Outbred mice. Scientific Data. (2023). https://doi.org/10.1038/s41597-023-02426-2

AUTHORS

6 · 3 CENTRES

Vivek M Philip, Hao He, Michael C Saul, Price E Dickson, Jason A Bubier, Elissa J Chesler

1The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME 04605 USA
2The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA
3Department of Biomedical Sciences, Joan C. Edwards School of Medicine Marshall University, Huntington, WV 25703 USA