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TL;DR
It concludes that advances in these fields will improve the prevention and development of targeted therapies for the disease.
Current Issues in Molecular Biology · 3 authors, 5 centres
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It concludes that advances in these fields will improve the prevention and development of targeted therapies for the disease.
It synthesizes findings from genomic, epigenomic, transcriptomic, proteomic, and metabolomic studies to explain the genetic predisposition, immune dysfunctions, and skin barrier abnormalities involved in AD. The authors highlight key discoveries like the filaggrin gene's impact and note associations with other atopic conditions. The review concludes that these multi-omics approaches have significantly advanced the understanding of AD and will be crucial for developing immunomodulatory systemic therapies and improving prevention strategies.