Glycine and N-Acetylcysteine (GlyNAC) Combined with Body Weight Support Treadmill Training Improved Spinal Cord and Skeletal Muscle Structure and Function in Rats with Spinal Cord Injury

Nutrients · 15 authors, 3 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

GlyNAC alone improved BBB scores and gait symmetry.

Full summary

227 CHARS

GlyNAC alone improved BBB scores and gait symmetry. Limitations include the absence of a reported sample size, a relatively short study duration precluding assessment of long-term effects, and use of only one training modality.

STUDY TYPE

other

SPECIALTY

preclinical research

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10649910

Glycine and N-Acetylcysteine (GlyNAC) Combined with Body Weight Support Treadmill Training Improved Spinal Cord and Skeletal Muscle Structure and Function in Rats with Spinal Cord Injury

Nutrients

READ THE FULL PAPER

ABSTRACT

Skeletal muscle atrophy is a frequent complication after spinal cord injury (SCI) and can influence the recovery of motor function and metabolism in affected patients. Delaying skeletal muscle atrophy can promote functional recovery in SCI rats. In the present study, we investigated whether a combination of body weight support treadmill training (BWSTT) and glycine and N-acetylcysteine (GlyNAC) could exert neuroprotective effects, promote motor function recovery, and delay skeletal muscle atrophy in rats with SCI, and we assessed the therapeutic effects of the double intervention from both a structural and functional viewpoint. We found that, after SCI, rats given GlyNAC alone showed an improvement in Basso–Beattie–Bresnahan (BBB) scores, gait symmetry, and results in the open field test, indicative of improved motor function, while GlyNAC combined with BWSTT was more effective than either treatment alone at ameliorating voluntary motor function in injured rats. Meanwhile, the results of the skeletal muscle myofiber cross-sectional area (CSA), hindlimb grip strength, and acetylcholinesterase (AChE) immunostaining analysis demonstrated that GlyNAC improved the structure and function of the skeletal muscle in rats with SCI and delayed the atrophication of skeletal muscle.

CITATION EXPORT

Xin Xu, Hua-Yong Du, Zuliyaer Talifu et al.. Glycine and N-Acetylcysteine (GlyNAC) Combined with Body Weight Support Treadmill Training Improved Spinal Cord and Skeletal Muscle Structure and Function in Rats with Spinal Cord Injury. Nutrients. (2023). https://doi.org/10.3390/nu15214578

AUTHORS

15 · 3 CENTRES

Xin Xu, Hua-Yong Du, Zuliyaer Talifu, Chun-Jia Zhang, Ze-Hui Li, Wu-Bo Liu, Yi-Xiong Liang, Xu-Luan Xu, Jin-Ming Zhang, De-Gang Yang, Feng Gao, Liang-Jie Du, Yan Yu, Ying-Li Jing, Jian-Jun Li

1School of Rehabilitation, Capital Medical University, Beijing 100069, China; [email protected] (X.X.);
2School of Population Medicine and Public Health, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China
3Department of Orthopedics, Qilu Hospital of Shandong University, Jinan 250100, China

EDITOR / REVIEWER

David C. Nieman, Barbara Obermayer-Pietsch, David Russ