Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review

Digestive Diseases and Sciences · 5 authors, 4 centres

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TL;DR

This systematic review analyzed nine human observational studies to assess the role of gut microbiota in diverticular disease. The review found that Enterobacteriaceae are the microbiota most commonly associated with the disease, but the evidence is limited due to high heterogeneity among studies.

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This systematic review searched literature to clarify the role of the intestinal microbiome in colonic diverticulitis. Nine studies were included, focusing on patients with diverticular disease (DD), with only one study focused on acute diverticulitis (AD). The review found that Enterobacteriaceae are the microbiota most associated with the disease, followed by Bifidobacteria. The limitations include small sample sizes and inconsistent comparisons. The authors conclude that further research is needed to clarify the microbiota's role and to develop potential targeted therapies.

STUDY TYPE

systematic_review

SPECIALTY

gastroenterology

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100% · A

ORIGINAL PAPER

PMC10011305

Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review

Digestive Diseases and Sciences

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ABSTRACT

Introduction Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries. In the last years, different articles have suggested a possible role of the intestinal microbiome in DD pathogenesis and in the development of acute diverticulitis (AD). This systematic review aimed to clarify the current knowledge on the role of the intestinal microbiome in colonic diverticulitis in different stages according to the 2009 PRISMA guidelines. Materials and Methods Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, Cochrane Oral Health Group Specialized Register, ProQuest Dissertations and Theses Database, and Google Scholar. Patients with any stage of disease were included. The Newcastle-Ottawa scale for case-control and cohort studies was used for the quality assessment of the selected articles. Results Overall, nine studies were included in the review. Only one article was focused on patients with AD, while all other articles only considered patients with DD without acute inflammation signs. Enterobacteriaceae seems to be the microbiota most associated with the disease, followed by Bifidobacteria. Conclusions All the included studies showed great heterogeneity in population characteristics and sampling methods. Therefore, given the high prevalence of colonic diverticulitis in the general population, further studies are needed to clarify the role of the intestinal microbiome, paving the way to new target therapies with important social implications.

CITATION EXPORT

Elisa Reitano, Elisa Francone, Elisa Bona et al.. Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review. Digestive Diseases and Sciences. (2022). https://doi.org/10.1007/s10620-022-07600-x

AUTHORS

5 · 4 CENTRES

Elisa Reitano, Elisa Francone, Elisa Bona, Antonia Follenzi, Sergio Gentilli

1grid.16563.370000000121663741Department of Translational Medicine, Maggiore Della Carità University Hospital, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
2grid.16563.370000000121663741Division of General Surgery, Department of Health Sciences, Maggiore Della Carità University Hospital, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
3Department of Surgery, IRCCS Ospedale San Martino, Largo R. Benzi 10, 16132 Genoa, Italy
4grid.16563.370000000121663741Department of Science and Innovation in Technologies, University of Eastern Piedmont, Piazza San Eusebio 5, 13100 Vercelli, Italy