International Journal of Molecular Sciences · 5 authors, 6 centres
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This narrative review explores evidence that COVID-19 can cause gut dysbiosis, which may exacerbate inflammation and oxidative stress, creating a cycle that worsens disease. It discusses the potential of modulating gut microbiota as a strategy for prevention and therapy.
This narrative review discusses the relationship between COVID-19 and gut microbiota dysbiosis, highlighting that the virus can alter gut bacterial composition, decreasing probiotic strains. This dysbiosis may exacerbate inflammation and oxidative stress, potentially contributing to disease progression. The review explores molecular mechanisms, noting that certain bacteria produce metabolites targeting viral proteins and that decreases in short-chain fatty acids influence inflammatory states. It suggests that modulating the gut microbiota, through maintaining intestinal health and microbial diversity, could be a potential approach for preventing and treating SARS-CoV-2 infection. The authors emphasize the bidirectional relationship between COVID-19 and gut health and the importance of further research into the intestinal virome and mycobiome for future pandemic preparedness.
