cohort·epidemiology, public health, preclinical research, biomedical research, endocrinology·PMC10611739
Gut microbiota impacts bone via Bacteroides vulgatus -valeric acid-related pathways
Nature Communications · 32 authors, 9 centres
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It was complemented by ovariectomized (OVX) mouse models and in vitro experiments.
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It was complemented by ovariectomized (OVX) mouse models and in vitro experiments. Human analysis showed negative associations between GM biodiversity, specific functional pathways, and BMD. In mice, B. vulgatus decreased VA levels and increased bone resorption, while VA treatment suppressed bone resorption. In vitro, VA inhibited osteoclast maturation and promoted osteoblast activity, partly by modulating NF-κB signaling. Limitations include differences in association sites between discovery and replication cohorts and the need for further mechanistic studies.
