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TL;DR
This study measured circulating Hedgehog interacting protein (HHIP) in 452 young women and found that levels are significantly higher in obese women compared to controls.
Annals of Medicine · 12 authors, 4 centres
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This study measured circulating Hedgehog interacting protein (HHIP) in 452 young women and found that levels are significantly higher in obese women compared to controls.
Participants underwent euglycemic-hyperinsulinemic clamps and oral glucose tolerance tests. Obese women had significantly elevated circulating HHIP levels, which correlated positively with body mass index, glucose, insulin, and insulin resistance, and negatively with the clamp M-value and adiponectin. Oral glucose challenge and hyperinsulinemic clamp tests suggested HHIP is regulated by blood glucose but less so by insulin. 6-week interventions with metformin or liraglutide improved metabolic parameters. The study suggests HHIP may be a potential biomarker for obesity and insulin resistance in young women, but notes limitations including the inclusion of only young Han women and the need for larger prospective studies.