SEARCHCROSS-SECTIONALinternal medicine, endocrinology

cross-sectional·internal medicine, endocrinology, hematology, epidemiology, public health·PMC10212162

Hematological abnormalities and associated factors among metabolic syndrome patients at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia

PLOS ONE · 6 authors, 3 centres

AI SUMMARY

FIDELITY 100%

POPULATION384 metabolic syndrome patients at the University of Gondar comprehensive specialized hospital

INTERVENTION

COMPARISON

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AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

A cross-sectional study of 384 patients with metabolic syndrome in Ethiopia found that anemia was the most common hematological abnormality at 13.3%, with factors like male sex, rural residence, and antihypertensive medication use associated with higher odds.

Full summary

432 CHARS

This hospital-based cross-sectional study assessed the prevalence of hematological abnormalities in 384 metabolic syndrome patients. The study found anemia in 13.3% of patients, followed by leukocytosis (2.9%) and thrombocytosis (2.3%). Multivariate analysis identified male sex, rural residency, taking antihypertensive medications, elevated triglycerides, and lower body mass index as factors significantly associated with anemia.

PICO

PPOPULATION

384 metabolic syndrome patients at the University of Gondar comprehensive specialized hospital

OOUTCOME

Magnitude of hematological abnormalities (anemia, leukopenia, leukocytosis, thrombocytopenia, thrombocytosis) and associated factors

STUDY TYPE

cross-sectional

SPECIALTY

internal medicine

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10212162

Hematological abnormalities and associated factors among metabolic syndrome patients at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia

PLOS ONE

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ABSTRACT

Abstract Background Metabolic Syndrome (MetS) is a cluster of interconnected metabolic diseases. Hematological abnormalities are common but neglected complications of MetS. Thus, this study aimed to determine the magnitude of hematological abnormalities and their associated factors among MetS patients at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia. Method A hospital-based cross-sectional study was conducted at the University of Gondar comprehensive specialized hospital from March to May 2022. A total of 384 MetS patients were selected using a systematic random sampling technique. Data were collected using pre-tested structured questionnaires and checklists. Anthropometric and blood pressure measurements were taken, and blood sample was collected for complete blood count determination. Stool and blood film examinations were performed to detect intestinal and malaria parasites, respectively. Data were entered into EpiData 3.1 and analyzed by Stata 14.0 software. Bivariate and multivariate logistic regression models were fitted to identify factors associated with hematological abnormalities. A p-value of < 0.05 was considered statistically significant. Results The magnitude of anemia, leukopenia, leukocytosis, thrombocytopenia, and thrombocytosis was found to be 13.3%, 0.5%, 2.9%, 1.6%, and 2.3%, respectively. Being male (AOR = 2.65, 95% CI: 1.14, 6.20), rural residency (AOR = 5.79, 95% CI: 1.72, 19.51), taking antihypertensive medications (AOR = 3.85, 95% CI: 1.16, 12.78), having elevated triglyceride level (AOR = 2.21, 95% CI: 1.03, 4.75), and being overweight or obese (AOR = 0.32, 95% CI: 0.16, 0.64) were significantly associated with anemia. Conclusions Anemia was the most prevalent hematological abnormality identified in the present study, followed by leukocytosis and thrombocytosis. Anemia was a mild public health problem among MetS patients in the study area. Routine anemia screening for all MetS patients, especially for those with significant associated factors, may help in the early detection and effective management of anemia, which subsequently improves the patients’ quality of life.

CITATION EXPORT

Amanuel Kelem, Elias Shiferaw, Tiruneh Adane et al.. Hematological abnormalities and associated factors among metabolic syndrome patients at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0286163

AUTHORS

6 · 3 CENTRES

Amanuel Kelem, Elias Shiferaw, Tiruneh Adane, Desalegn Admassu Ayana, Desalegn Admassu Ayana, Desalegn Admassu Ayana

1Department of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia
2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
3Haramaya University, ETHIOPIA