SEARCHSYSTEMATIC_REVIEWobstetrics and gynecology, epidemiology

systematic_review·obstetrics and gynecology, epidemiology, systematic review, hematology, public health·PMC10034471

High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review

Cureus · 2 authors, 1 centre

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TL;DR

This scoping review of studies from 2010 to 2022 found an association between elevated maternal homocysteine levels in pregnancy and an increased risk of placenta-mediated complications, including preeclampsia, fetal growth restriction, abruption, and early spontaneous abortions.

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This scoping review analyzed research papers from 2010 to 2022 to integrate evidence on the association between elevated maternal homocysteine levels in early pregnancy and placenta-mediated complications. The review identified that homocysteine levels fluctuate during pregnancy and are influenced by regional, cultural, and socioeconomic factors. The central result is a reported connection between high homocysteine and complications such as preeclampsia, fetal growth restriction, abruption, recurrent pregnancy losses, and maternal/newborn death. The authors note that further research is needed to identify genetic components of homocysteine metabolism abnormalities and to determine optimal timing for testing to enable preventative intervention.

STUDY TYPE

systematic_review

SPECIALTY

obstetrics and gynecology

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AI pipeline

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ORIGINAL PAPER

PMC10034471

High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review

Cureus

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ABSTRACT

Abstract There is already abundant corroboration indicating that elevated serum homocysteine levels may be related to the risk of coronary, cerebral, and peripheral arterial diseases. High homocysteine levels have often been associated with placental vasculopathies and complications related to the placenta, such as fetal growth restriction, Abruption, hypertensive disorders of pregnancy, and recurrent abortions. This scoping review aims to integrate the currently available scientific literature and fill the gaps in our understanding of homocysteine metabolism during pregnancy and its relationship to placenta-mediated complications. Moreover, to summarize the existing literature on the correlation between raised maternal homocysteine levels in early gestation and its association with placenta-mediated complications. We developed this scoping review article by performing a literature review as per the Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines and the search was conducted using PRISMA-S (an extension to PRISMA focusing on reporting the search components of systematic reviews) guidelines. The research question was clarified and modified using keywords with important literature published online between 2010 and 2022, which were included from PubMed, and Google Scholar databases with recognized titles and abstracts were examined and cross-checked for case overlap to choose the original reports. A summary of the descriptive data was organized according to the clinical manifestations (symptoms, imaging, and laboratory results) and outcomes (maternal and perinatal). In conclusion, a review of research papers from 2010 to 2022 showed that homocysteine levels during pregnancy fluctuate and are probably influenced by a population's regional, cultural, and socioeconomic status. According to the data, there is an association between elevated homocysteine levels and complications of pregnancies, such as early spontaneous abortions, pre-eclampsia, fetal development restriction, and abruption, as well as in certain cases of maternal and fetal mortality. Keywords: recurrent pregnancy loss, placental abruption, pre-eclampsia, fetal growth restriction, placenta mediated complications, hyperhomocysteinemia, serum homocysteine

CITATION EXPORT

Priyanka Thakur, Anuja Bhalerao. High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review. Cureus. (2023). https://doi.org/10.7759/cureus.35244

AUTHORS

2 · 1 CENTRES

Priyanka Thakur, Anuja Bhalerao

1 Obstetrics and Gynaecology, N.K.P. Salve Institute of Medical Sciences & Research Centre and Lata Mangeshkar Hospital, Nagpur, IND