Life · 9 authors, 4 centres
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This rabbit experiment tested three maintenance strategies after induced brain death to simulate organ donor care. The strategy combining fluid expansion, norepinephrine, and comprehensive hormone therapy (Group D) resulted in better hemodynamic stability, glycemic and sodium control, and reduced early histological signs of organ ischemia.
This preclinical study used a rabbit model to evaluate three potential maintenance strategies for brain-dead (BD) organ donors: crystalloid infusion alone (Group B), crystalloid plus norepinephrine (Group C), and a comprehensive strategy with crystalloid, vasopressin, levothyroxine, methylprednisolone, and norepinephrine if needed (Group D). Compared to controls and simpler strategies, Group D showed superior hemodynamic stability with higher mean arterial pressure and reduced need for fluid and vasopressor infusions. Group D also demonstrated better control of sodium and glucose levels. Histological analysis revealed that Group D had less renal tubular cell swelling and hepatic steatosis, with tissue characteristics closer to the non-BD control group, suggesting reduced early ischemia. The findings suggest that a comprehensive hormone and vasopressor strategy may optimize donor management by improving physiological control and organ perfusion, though direct human clinical translation requires further investigation.
