SEARCHNARRATIVE_REVIEWophthalmology, retina

narrative_review·ophthalmology, retina, preclinical research, biomedical research·PMC10401416

Human retinal secretome: A cross-link between mesenchymal and retinal cells

World Journal of Stem Cells · 8 authors, 13 centres

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TL;DR

This narrative review examines the cross-talk between secretomes from mesenchymal stem cells (MSCs) and retinal cells (RPE, Müller glia) in the context of retinal disease therapy.

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This is a narrative review summarizing preclinical evidence on the paracrine cross-talk between mesenchymal stem cell (MSC) and retinal cell secretomes. Conversely, retinal cell secretomes can influence MSC phenotype. The central implication is that understanding and manipulating this cross-talk could lead to novel, cell-free therapies for retinal diseases. The review highlights key factors like FGF, CXCL12, and miRNAs but notes major challenges remain, including specific characterization of factors, improved ocular delivery methods, and developing personalized therapeutic combinations.

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narrative_review

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ophthalmology

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ORIGINAL PAPER

PMC10401416

Human retinal secretome: A cross-link between mesenchymal and retinal cells

World Journal of Stem Cells

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ABSTRACT

In recent years, mesenchymal stem cells (MSC) have been considered the most effective source for regenerative medicine, especially due to released soluble paracrine bioactive components and extracellular vesicles. These factors, collectively called the secretome, play crucial roles in immunomodulation and in improving survival and regeneration capabilities of injured tissue. Recently, there has been a growing interest in the secretome released by retinal cytotypes, especially retinal pigment epithelium and Müller glia cells. The latter trophic factors represent the key to preserving morphofunctional integrity of the retina, regulating biological pathways involved in survival, function and responding to injury. Furthermore, these factors can play a pivotal role in onset and progression of retinal diseases after damage of cell secretory function. In this review, we delineated the importance of cross-talk between MSCs and retinal cells, focusing on common/induced secreted factors, during experimental therapy for retinal diseases. The cross-link between the MSC and retinal cell secretomes suggests that the MSC secretome can modulate the retinal cell secretome and vice versa. For example, the MSC secretome can protect retinal cells from degeneration by reducing oxidative stress, autophagy and programmed cell death. Conversely, the retinal cell secretome can influence the MSC secretome by inducing changes in MSC gene expression and phenotype.

CITATION EXPORT

Luigi Donato, Concetta Scimone, Simona Alibrandi et al.. Human retinal secretome: A cross-link between mesenchymal and retinal cells. World Journal of Stem Cells. (2023). https://doi.org/10.4252/wjsc.v15.i7.665

AUTHORS

8 · 13 CENTRES

Luigi Donato, Concetta Scimone, Simona Alibrandi, Sergio Zaccaria Scalinci, Domenico Mordà, Carmela Rinaldi, Rosalia D'Angelo, Antonina Sidoti

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy
Department of Biomolecular Strategies, Genetics and Cutting-Edge Therapies, Euro-Mediterranean Institute of Science and Technology, Palermo 90139, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy
Department of Biomolecular Strategies, Genetics and Cutting-Edge Therapies, Euro-Mediterranean Institute of Science and Technology, Palermo 90139, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy
Department of Biomolecular Strategies, Genetics and Cutting-Edge Therapies, Euro-Mediterranean Institute of Science and Technology, Palermo 90139, Italy
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina 98125, Italy. [email protected]
Department of Medical and Surgical Sciences, University of Bologna, Bologna 40121, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy
Department of Biomolecular Strategies, Genetics and Cutting-Edge Therapies, Euro-Mediterranean Institute of Science and Technology, Palermo 90139, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98125, Italy