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TL;DR
This is a case report of a 69-year-old woman with chronic kidney disease and systemic lupus erythematosus who developed renal phospholipidosis after 25 years of hydroxychloroquine therapy, which resolved after drug discontinuation.
Case Reports in Nephrology and Dialysis · 5 authors, 2 centres
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This is a case report of a 69-year-old woman with chronic kidney disease and systemic lupus erythematosus who developed renal phospholipidosis after 25 years of hydroxychloroquine therapy, which resolved after drug discontinuation.
The authors present a case of a 69-year-old female patient with chronic kidney disease and systemic lupus erythematosus who underwent a kidney biopsy for rising serum creatinine. The finding was attributed to 25 years of continuous hydroxychloroquine use. After discontinuation of the drug, renal function parameters remained stable over a 1-year follow-up. The case discussion highlights that the prevalence and clinical relevance of hydroxychloroquine-induced renal phospholipidosis are unclear, with heterogeneous time to onset reported in the literature. It raises the question of whether impaired renal function increases the risk of drug accumulation and phospholipidosis. A review of differential diagnoses is provided, listing numerous pharmaceuticals, genetic diseases, and other factors that can cause renal phospholipidosis.