Food Science & Nutrition · 8 authors, 2 centres
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This study used GC–MS, UHPLC‐Q‐Exactive Orbitrap‐MS, and HPLC–PDA to comprehensively profile the chemical constituents of Geqingpi (GQP), a type of Citri Reticulatae Pericarpium Viride. The analysis identified 56 volatile and 42 nonvolatile compounds, with high concentrations of flavonoids like hesperidin. The work provides a chemical basis for quality control but does not assess biological activity or clinical relevance.
Citri Reticulatae Pericarpium Viride (CRPV), specifically Geqingpi (GQP), is a traditional Chinese medicine with purported uses for conditions like dyspepsia and liver disorders. However, its complete chemical profile was lacking. This study aimed to identify and quantify the volatile and nonvolatile constituents of GQP using a combination of analytical techniques. Volatile components were analyzed via GC–MS, nonvolatile components via UHPLC‐Q‐Exactive Orbitrap–MS, and seven key bioactive compounds were quantified using HPLC–PDA. The results identified 56 volatile compounds, with terpenes being dominant (70%), led by γ‐terpinene (33.39%) and D‐limonene (22.95%). UHPLC–MS analysis revealed 42 nonvolatile compounds, primarily flavonoids (23), including 9 compounds reported for the first time in CRPV. Quantitative HPLC–PDA showed hesperidin was highly abundant (160.78 ± 0.95 mg·g⁻¹), far exceeding pharmacopeial requirements. Significant amounts of nobiletin (4.29 ± 0.02 mg·g⁻¹), tangeretin (3.07 ± 0.01 mg·g⁻¹), synephrine (5.57 ± 0.05 mg·g⁻¹), and limonin (4.11 ± 0.10 mg·g⁻¹) were also found. Key limitations include that this is a phytochemical analysis without any evaluation of the identified compounds' biological activities or clinical efficacy. The study successfully provides a comprehensive chemical foundation for future quality control and pharmacological research on GQP.
