ALTEX · 4 authors, 2 centres
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This study assembled a compendium of approximately 280 candidate reference chemicals with activity on ten protein family targets in the retinoid pathway using data extraction from public databases and literature. The goal was to provide a resource for developing in vitro tests to predict developmental toxicity without animal testing.
This work aimed to build a compendium of candidate reference chemicals for in vitro testing of the retinoid pathway to predict developmental toxicity. Using data extraction methods, the authors assembled a set of approximately 280 chemicals with demonstrated activity on ten protein targets from sources like Protein Data Bank, ChEMBL, ToxCast/Tox21, and PubMed. A literature exploration using an updated Abstract Sifter tool showed that about 64% of these chemicals have some connections to citations about developmental toxicity, and about 58 chemicals have literature supporting links to limb defects. The discussion highlights disparities in available data across targets and challenges in linking molecular activity to downstream adverse outcomes, emphasizing the need for complex in vitro systems. The study's primary implication is to facilitate the development of new testing programs and alternative methods by providing a centralized resource of reference chemicals.
