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TL;DR
This cohort study of 35 bariatric surgery patients found that weight loss from surgery was associated with reduced DNA damage and lipid peroxidation, alongside decreased DNA repair activity, six months after the procedure.
Antioxidants · 12 authors, 6 centres
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This cohort study of 35 bariatric surgery patients found that weight loss from surgery was associated with reduced DNA damage and lipid peroxidation, alongside decreased DNA repair activity, six months after the procedure.
The study found a significant, time-dependent decrease in overall DNA damage (54% reduction) and malondialdehyde levels, a marker of lipid peroxidation, six months after surgery. Activities of base excision repair (BER) and nucleotide excision repair (NER) pathways also decreased over the study period. Telomere length showed a non-significant increase over six months. Proteomic analysis revealed downregulation of inflammation markers like CRP and SAA1. The authors note the decrease in DNA repair was unexpected and may be an adaptive response to lower DNA damage levels, possibly influenced by post-surgical micronutrient supplementation.