POPULATIONPatients with advanced hepatocellular carcinoma in the palliative arm of the SORAMIC trial
INTERVENTIONBody composition parameters (skeletal muscle and adipose tissue) measured at the L3 level on baseline abdominal CT
COMPARISONNone (observational subanalysis of a randomized trial)
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This exploratory subanalysis of a randomized trial assessed body composition via CT scans in 369 patients with advanced liver cancer receiving palliative therapy. It found no relevant association between skeletal muscle or adipose tissue parameters and overall survival.
Full summary
1,034 CHARS
This study is an exploratory subanalysis of the prospective, randomized controlled SORAMIC trial. Patients were in either a combined sorafenib and selective internal radiation therapy (SIRT) group (n=192) or a sorafenib-only group (n=177). A broad set of skeletal muscle and adipose tissue parameters was measured at the L3 vertebral level. The primary analysis correlated these body composition parameters with overall survival. The median overall survival was 9.9 months for the entire cohort, with 10.8 months for the SIRT/sorafenib group and 9.2 months for the sorafenib group. The study found no relevant association between any body composition parameter and overall survival in the overall cohort or in either treatment subgroup. Limitations include potential selection bias from excluding patients without a baseline CT scan and the analysis being restricted to patients with liver-dominant disease. The authors conclude that body composition parameters do not serve for patient allocation in this palliative treatment cohort.
PICO
PPOPULATION
Patients with advanced hepatocellular carcinoma in the palliative arm of the SORAMIC trial
IINTERVENTION
Body composition parameters (skeletal muscle and adipose tissue) measured at the L3 level on baseline abdominal CT
