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TL;DR
This case-control study of a northeastern Han Chinese population found that specific genetic variations (SNPs rs1800686 and rs3765459) in the CD40 gene were associated with a decreased risk of developing cervical squamous cell carcinoma.
BMC Cancer · 9 authors, 3 centres
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This case-control study of a northeastern Han Chinese population found that specific genetic variations (SNPs rs1800686 and rs3765459) in the CD40 gene were associated with a decreased risk of developing cervical squamous cell carcinoma.
The study investigated the association between three CD40 gene single nucleotide polymorphisms (SNPs) and the risk of cervical squamous cell carcinoma (CSCC) and high-grade squamous intraepithelial lesions (HSIL) in a northeastern Han Chinese population. Using a case-control design, researchers genotyped 421 CSCC patients, 594 HSIL patients, and 504 healthy controls. The analysis revealed that the AA genotype of rs1800686 and rs3765459 were associated with a statistically significant reduced risk of CSCC compared to other genotypes, even after FDR correction. However, these associations were not significant after the more conservative Bonferroni correction. The study also found correlations between specific CD40 SNP genotypes and clinical parameters like parity, D-dimer levels, and squamous cell carcinoma antigen levels. Limitations included incomplete HPV data for many participants and the lack of functional studies linking the SNPs to CD40 expression levels. The findings suggest CD40 gene polymorphisms may influence CSCC susceptibility, but further research in larger cohorts is needed.