Impact of cigarette smoking on fluorescence lifetime of ocular fundus

Scientific Reports · 6 authors, 3 centres

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This cross-sectional study used fluorescence lifetime imaging ophthalmoscopy to compare retinal fluorescence lifetimes between young, healthy smokers and non-smokers. It found a statistically significant, smoking dose-dependent elongation of the mean fluorescence lifetime in specific retinal regions of smokers.

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This cross-sectional study investigated the impact of cigarette smoking on the fluorescence lifetime (FLT) of retinal fluorophores in young, healthy adults. Results showed a statistically significant difference in FLT between non-smokers and smokers. Specifically, the fast component (τ1) and mean FLT (τm) showed a smoking dose-dependent elongation at the fovea and inner ring in the short-wavelength channel (SSC). The study suggests these changes may reflect alterations in retinal metabolic state, possibly related to flavins, advanced glycation endproducts, or macular pigment. The findings highlight FLIO's potential as a tool to detect early, subtle retinal microenvironmental changes caused by lifestyle factors.

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cross-sectional

SPECIALTY

ophthalmology

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ORIGINAL PAPER

PMC10352358

Impact of cigarette smoking on fluorescence lifetime of ocular fundus

Scientific Reports

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ABSTRACT

Abstract Cigarette smoking is known to adversely affect cellular metabolism and is a risk factor for various retinal diseases. Fluorescence lifetime imaging ophthalmoscopy (FLIO) has the potential to detect metabolic changes in the ocular fundus. Aim of this study was to analyze the influence of cigarette smoking on fluorescence lifetime (FLT) of healthy eyes using FLIO. Twenty-six non-smokers and 28 smokers aged between 20 and 37 years without systemic and ocular diseases were investigated by FLIO (excitation: 473 nm, emission: short spectral channel (SSC) 498–560 nm, long spectral channel (LSC) 560–720 nm). The FLT at the ETDRS grid regions were analyzed and compared. In SSC, the mean FLT (τ m ) of smokers was significantly longer in the ETDRS inner ring region, whereas the τ m in LSC was significantly shorter in the outer ring. For the long component (τ 2 ), smokers with pack year < 7.11 showed significantly shorter τ 2 in SSC than non-smokers and the smokers with pack year ≥ 7.11. There were no significant differences in retinal thickness. The lack of obvious structural differences implies that the observed FLT changes are likely related to smoking-induced metabolic changes. These results suggest that FLIO may be useful in assessing retinal conditions related to lifestyle and systemic metabolic status. Subject terms: Diagnostic markers, Translational research

CITATION EXPORT

Svenja Rebecca Sonntag, Marie Kreikenbohm, Giulia Böhmerle et al.. Impact of cigarette smoking on fluorescence lifetime of ocular fundus. Scientific Reports. (2023). https://doi.org/10.1038/s41598-023-37484-4

AUTHORS

6 · 3 CENTRES

Svenja Rebecca Sonntag, Marie Kreikenbohm, Giulia Böhmerle, Jessica Stagge, Salvatore Grisanti, Yoko Miura

1Department of Ophthalmology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
2Institute of Biomedical Optics, University of Lübeck, Lübeck, Germany
3Medical Laser Center Lübeck, Lübeck, Germany