SEARCHNARRATIVE_REVIEWneurology, immunology

narrative_review·neurology, immunology, preclinical research, biomedical research, gastroenterology·PMC10179357

Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions

International Journal of Molecular Sciences · 7 authors, 5 centres

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TL;DR

The central conclusion is that while promising, translational application to humans is limited by differences between models and a lack of proven causality.

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A major limitation noted is the low similarity between these experimental models and humans, which hinders direct translational relevance. The review emphasizes that for future progress, researchers must first establish causality and then define the specific microbial compositions critical for affecting particular pathologies.

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narrative_review

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neurology

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ORIGINAL PAPER

PMC10179357

Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions

International Journal of Molecular Sciences

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ABSTRACT

Abstract It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions. Keywords: gut microbiota, peripheral nerve, nerve injury and regeneration, short chain fatty acid

CITATION EXPORT

Sonia Calabrò, Svenja Kankowski, Matilde Cescon et al.. Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms24098061

AUTHORS

7 · 5 CENTRES

Sonia Calabrò, Svenja Kankowski, Matilde Cescon, Giovanna Gambarotta, Stefania Raimondo, Kirsten Haastert-Talini, Giulia Ronchi

1Department of Molecular Medicine, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy; [email protected] (S.C.); [email protected] (M.C.)
2Department of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy
3Hannover Medical School, Institute of Neuroanatomy and Cell Biology, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (S.K.); [email protected] (K.H.-T.)
4Department of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 10, Orbassano, 10043 Torino, Italy; [email protected] (G.G.); [email protected] (S.R.)
5Center for Systems Neuroscience Hannover (ZSN), Buenteweg 2, 30559 Hannover, Germany