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RCT·endocrinology, nutrition, clinical nutrition, public health, neurology·PMC10051212

Impact of lifestyle modification on glycemic control and cognitive function among Type II diabetes mellitus patients

Future Science OA · 15 authors, 4 centres

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TL;DR

The intervention group showed significant improvements in HbA1c, cognitive function, and other metabolic markers compared to the control group.

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The interventional group received a 6-month lifestyle modification program featuring health education sessions on diet, physical activity, and cognitive games. After 6 months, the interventional group demonstrated significant improvements from baseline in weight, BMI, HbA1c, cognitive function (ACE-III score), malondialdehyde (MDA), glutathione peroxidase (GPx), and lipid profile (p<0.01). When compared directly, the interventional group also had significantly better cognitive function, systolic blood pressure, glycemic control, glutathione reductase (GR), and lipid panel than the conventional group (p<0.05). The findings suggest lifestyle modification is beneficial for glycemic control and cognitive function in T2DM patients.

STUDY TYPE

RCT

SPECIALTY

endocrinology

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AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10051212

Impact of lifestyle modification on glycemic control and cognitive function among Type II diabetes mellitus patients

Future Science OA

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ABSTRACT

Aim Assessing impact of lifestyle modification on Type 2 diabetes mellitus (T2DM) glycemic control and cognitive function. Subjects & methods Prospective study was conducted on T2DM patients (92 patients as interventional group and 92 patients conventional therapy). Results After 6 months, significant improvements of HbA1c, oxidant and antioxidant, lipid profile, and cognitive function among only the interventional group (p < 0.05). Using logistic analysis, conventional therapy, DM duration >10 years, lower education, HbA1c baseline >7 were significant predictive risks for uncontrolled DM (AOR 4.2, 2.9, 2.7 and 2.2, respectively). While, conventional therapy, baseline mild cognitive impairment (MCI) and females were significant risks for MCI (AOR 11.5, 10.8 and 4.8, respectively). Conclusion Lifestyle modification is a very important for glycemic control and cognitive function. Clinical Trial Registration : NCT04891887 ( ClinicalTrials.gov )

CITATION EXPORT

Iman I Salama, Samia M Sami, Somaia I Salama et al.. Impact of lifestyle modification on glycemic control and cognitive function among Type II diabetes mellitus patients. Future Science OA. (2023). https://doi.org/10.2144/fsoa-2022-0060

AUTHORS

15 · 4 CENTRES

Iman I Salama, Samia M Sami, Somaia I Salama, Ghada A Abdel-Latif, Ahmed Aboulghate, Hala M Raslan, Amira Mohsen, Hanaa Rasmy, Mona Hamed Ibrahim, Mona MF Ganem, Aida M Abdelmohsen, Lobna A El-Etreby, Nihad A Ibrahim, Walaa A Fouad, Sherif E El-Deeb

1Community Medicine Research Department, National Research Center, Cairo, 12622, Egypt
2Child Health Department, National Research Center, Cairo, 12622, Egypt
3Internal Medicine Department, National Research Center, Cairo, 12622, Egypt
4Clinical & Chemical Pathology Department, Centre of Excellence, National Research Centre, Cairo, 12622, Egypt