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TL;DR
The central conclusion is that targeting NQO1 may be a promising strategy for new diagnostic and therapeutic compounds for neurological disorders.
Journal of Translational Medicine · 3 authors, 5 centres
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The central conclusion is that targeting NQO1 may be a promising strategy for new diagnostic and therapeutic compounds for neurological disorders.
This narrative review synthesizes existing literature on the regulatory role of NAD(P)H quinone dehydrogenase 1 (NQO1) in the central nervous system. The authors describe NQO1's mechanisms, including cellular detoxification, protection against oxidative stress, and modulation of inflammatory responses via pathways like neuroinflammation and immune cell activation. They note that NQO1 polymorphisms, such as C609T, are linked to neurological diseases like Alzheimer's and multiple sclerosis.