JPGN reports · 12 authors, 9 centres
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The study assessed clinical disease activity (via Pediatric Crohn’s Disease Activity Index and Pediatric Ulcerative Colitis Activity Index), biological activity (C-reactive protein, fecal calprotectin), disease severity, complications, surgery, and hospitalization over the last 12 months.
The study assessed clinical disease activity (via Pediatric Crohn’s Disease Activity Index and Pediatric Ulcerative Colitis Activity Index), biological activity (C-reactive protein, fecal calprotectin), disease severity, complications, surgery, and hospitalization over the last 12 months. Central results showed obesity was not associated with a decrease in disease remission or an increase in complicated disease progression in IBD overall, except for perianal abscesses and related surgery in overweight/obese CD patients (P < 0.001). There was a significant association between obesity and development of extraintestinal manifestations, specifically arthritis, in CD. In UC, obese patients had higher clinical activity scores but were still in clinical remission. Hospitalization rates were similar across weight groups. The findings suggest obesity in pediatric IBD correlates with specific complications in CD but does not uniformly worsen overall disease course.
