SEARCHOTHERepidemiology, public health

other·epidemiology, public health, surgery, observational study, preclinical research·PMC10450065

Impact of SARS-CoV-2 infection on postoperative complications of patients undergoing surgery after general outbreak in China: a protocol for multicentre prospective cohort study

BMJ Open · 5 authors, 2 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This is a study protocol for a multicentre prospective cohort study examining the impact of SARS-CoV-2 infection on postoperative complications among surgical patients in China following the 2022 pandemic wave.

Full summary

870 CHARS

This is a study protocol for a multicentre prospective observational cohort study across Chinese hospitals, investigating the association between SARS-CoV-2 infection and postoperative complications following the December 2022 pandemic wave. The study targets surgical patients receiving general or regional anaesthesia between January and December 2023, with a retrospective 2019 cohort as historical reference. Data will be extracted from health information and anaesthesia management systems, with COVID-19 information collected via online survey. Binomial regression with logit link and Cox regression with competing risks are planned analytical methods. No completed results are reported. The protocol acknowledges limitations including missing information in electronic medical records, ambiguous entries, and residual confounding inherent to observational design.

STUDY TYPE

other

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10450065

Impact of SARS-CoV-2 infection on postoperative complications of patients undergoing surgery after general outbreak in China: a protocol for multicentre prospective cohort study

BMJ Open

READ THE FULL PAPER

ABSTRACT

Abstract Introduction There is currently limited evidence addressing perioperative prognosis of surgical patients during COVID-19 pandemic; especially targeting on the Chinese population since the wave in 2022. Considering a distinct feature from the rest of the world demonstrated and the fast mutation and spread of the virus, evidence most relevant to China is urgently in need. The objective of this study is to seek for supporting evidence via evidence-based risk evaluations for postoperative complications to accumulate experience for coming infection waves. Methods and analysis This protocol proposes a multicentral, prospective, observational cohort study aiming to explore the link between SARS-CoV-2 infection and postoperative complications among surgical patients under general or regional anaesthesia between 16 January 2023 and 31 December 2023. A retrospective cohort covering the same period in 2019 is extracted for historic reference. Data are extracted from the health information system and anaesthesia information management system. The COVID-19 information is collected via an online survey. Missing values in weight or height will be imputed by each other with age and gender via multiple imputation. Other missing values will not be handled specially. Standard descriptive statistics will be reported followed by statistical modelling. Binomial regression with logit link is used for binary outcome. The time-to-event outcome is analysed using Cox regression with discharge from hospital further treated as a competing state. Hierarchical models will be assessed to account for temporal or central random effects. Temporal trends will be displayed with future expectations. Ethics and dissemination Ethical approval is obtained from the ethical committee in Xijing Hospital (No. KY20232002-C-1); approvals are expected for each participating institute. Verbal consent will be informed and obtained prior to online survey collection. Personal information remains confidential, and publications will be deidentified. Trial registration number NCT05677815 . Keywords: COVID-19, ANAESTHETICS, PUBLIC HEALTH

CITATION EXPORT

Ziyu Zheng, Baobao Gao, Gang Luo et al.. Impact of SARS-CoV-2 infection on postoperative complications of patients undergoing surgery after general outbreak in China: a protocol for multicentre prospective cohort study. BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2023-072608

AUTHORS

5 · 2 CENTRES

Ziyu Zheng, Baobao Gao, Gang Luo, Lini Wang, Chong Lei

1Department of Anesthesiology and Perioperative Medicine,Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
2Anesthesia Clinical Research Center, Xijing Hospital, Xi'an, Shaanxi, China