SEARCHCROSS-SECTIONALobstetrics and gynecology, endocrinology

cross-sectional·obstetrics and gynecology, endocrinology, epidemiology, public health, nutrition·PMC10007853

Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020

BMC Women's Health · 7 authors, 1 centre

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Serum uric acid levels were measured and infertility status was assessed via self-report.

Full summary

335 CHARS

Serum uric acid levels were measured and infertility status was assessed via self-report. Infertility was found in 649 (11.1%) of participants. Limitations include the cross-sectional design precluding causal inference, reliance on self-reported infertility, and lack of data on gynecological conditions such as endometriosis and PCOS.

STUDY TYPE

cross-sectional

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10007853

Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020

BMC Women's Health

READ THE FULL PAPER

ABSTRACT

Background There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed to find out if serum uric acid levels are independently related to female infertility. Methods From the National Health and Nutrition Examination Survey (NHANES) 2013–2020, a total sample of 5872 chosen female participants between the ages of 18 and 49 were identified for this cross-sectional study. The serum uric acid levels (mg/dL) of each participant were tested, and the reproductive health questionnaire was used to evaluate each subject's reproductive status. Both in the analyses of the full sample and each subgroup, logistic regression models were used to evaluate the relationship between the two variables. A stratified multivariate logistic regression model was used to perform the subgroup analysis based on serum uric acid levels. Results Infertility was found in 649 (11.1%) of the 5,872 female adults in this study, with greater mean serum uric acid levels (4.7 mg/dL vs. 4.5 mg/dL). Serum uric acid levels were associated with infertility in both the initial and adjusted models. According to multivariate logistic regression, the odds of female infertility were found to be significantly higher with rising serum uric acid levels (Q4 [≥ 5.2 mg/dL] vs. Q1 [≤ 3.6 mg/dL]), adjusted odds ratio [aOR] = 1.59, p = 0.002]. The data suggests that there is a dose–response relationship between the two. Conclusions The results from this nationally representative sample from the United States confirmed the idea that there is a link between increased serum uric acid levels and female infertility. Future research is necessary to evaluate the relationship between serum uric acid levels and female infertility and explicate the underlying mechanisms of this relationship.

CITATION EXPORT

Jiemei Liang, Xiting Chen, Jinfa Huang et al.. Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020. BMC Women's Health. (2023). https://doi.org/10.1186/s12905-023-02234-1

AUTHORS

7 · 1 CENTRES

Jiemei Liang, Xiting Chen, Jinfa Huang, Weizhe Nie, Qian Yang, Qitao Huang, Kaixian Deng

grid.284723.80000 0000 8877 7471Department of Gynaecology, Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde Foshan), No. 1, Jiazi Road, Lunjiao Town, Shunde District, Foshan, 528300 Guangdong China