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TL;DR
TH-HZ mice, with reduced catecholamine synthesis, showed greater deterioration across nervous, immune, and redox systems following stress compared to wild-type, with wild-type females responding more favorably than wild-type males.
International Journal of Molecular Sciences · 3 authors, 3 centres
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TH-HZ mice, with reduced catecholamine synthesis, showed greater deterioration across nervous, immune, and redox systems following stress compared to wild-type, with wild-type females responding more favorably than wild-type males.
This preclinical study compared wild-type (WT) and tyrosine hydroxylase haploinsufficient (TH-HZ) mice of both sexes under basal conditions and following a 10-minute immobilization punctual stress. Nervous function (sensorimotor skills, anxiety, exploration), innate and adaptive immune function, oxidative stress markers, and catecholamine concentrations in peritoneal leukocytes were evaluated. Under basal conditions, TH-HZ mice of both sexes exhibited impaired sensorimotor skills, higher anxiety, altered innate and adaptive immunity, and a pro-oxidant profile compared to WT controls. After stress, WT females showed improved innate immune function and maintained oxidative balance, while WT males exhibited impaired innate immunity, sterile inflammation, and oxidative stress. TH-HZ mice failed to mount an adequate stress response, showing deteriorated nervous function, impaired or unchanged immunity, and established oxidative stress. WT females increased adrenaline and noradrenaline after stress, while TH-HZ mice showed no catecholamine increase. These findings suggest catecholamine synthesis is critical for an adequate acute stress response in vivo, and that reduced catecholamine availability compromises behavioral, immune, and redox homeostasis.