SEARCHCOHORTophthalmology, glaucoma

cohort·ophthalmology, glaucoma, neurology, geriatrics, observational study·PMC10844352

In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus

International Ophthalmology · 9 authors, 5 centres

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TL;DR

The central result was that corneal hysteresis was significantly lower in the iNPH group.

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This prospective cohort study investigated ocular biomechanical properties in 24 non-shunted iNPH patients compared to 25 healthy controls using the Ocular Response Analyzer. The primary finding was a significantly lower median corneal hysteresis (CH) in iNPH patients (9.7 mmHg) versus controls (10.6 mmHg). No significant differences were observed in corneal-compensated intraocular pressure, Goldmann-correlated intraocular pressure, or corneal resistance factor between groups. The study suggests reduced CH may reflect decreased ability of the lamina cribrosa to compensate for pressure changes, potentially increasing glaucoma susceptibility in iNPH. Limitations include the relatively small cohort and the exclusion of shunted patients. The findings highlight the potential role of ocular biomechanics in glaucomatous risk for this population.

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cohort

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ophthalmology

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ORIGINAL PAPER

PMC10844352

In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus

International Ophthalmology

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ABSTRACT

Abstract Purpose Idiopathic normal pressure hydrocephalus (iNPH) is associated with an increased prevalence of open-angle glaucoma, attributed to variations of the pressure gradient between intraocular and intracranial compartments at the level of the lamina cribrosa (LC). As ocular biomechanics influence the behavior of the LC, and a lower corneal hysteresis (CH) has been associated to a higher risk of glaucomatous optic nerve damage, in this study we compared ocular biomechanics of iNPH patients with healthy subjects. Methods Twenty-four eyes of 24 non-shunted iNPH patients were prospectively recruited. Ocular biomechanical properties were investigated using the ocular response analyzer (Reichert Instruments) for the calculation of the CH, corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc). Results were compared with those of 25 eyes of 25 healthy subjects. Results In iNPH eyes, the median CH value and interquartile range (IQR) were 9.7 mmHg (7.8–10) and 10.6 mmHg (9.3–11.3) in healthy controls ( p = 0.015). No significant differences were found in IOPcc [18.1 mmHg (14.72–19.92) vs. 16.4 mmHg (13.05–19.6)], IOPg [15.4 mmHg (12.82–19.7) vs. 15.3 mmHg (12.55–17.35)], and CRF [9.65 mmHg (8.07–11.65) vs. 10.3 mmHg (9.3–11.5)] between iNPH patients and controls. Conclusions In iNPH patients, the CH was significantly lower compared to healthy subjects. This result suggests that ocular biomechanical properties may potentially contribute to the risk of development of glaucomatous optic nerve damage in iNPH patients. Keywords: Idiopathic normal pressure hydrocephalus, Ocular response analyzer, Ocular biomechanical properties, Open angle glaucoma

CITATION EXPORT

Nicola Valsecchi, Matilde Roda, Simone Febbraro et al.. In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus. International Ophthalmology. (2024). https://doi.org/10.1007/s10792-024-02922-3

AUTHORS

9 · 5 CENTRES

Nicola Valsecchi, Matilde Roda, Simone Febbraro, Eleonora Trolli, Giorgio Palandri, Giulia Giannini, David Milletti, Costantino Schiavi, Luigi Fontana

1Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, Bologna, Italy
2IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
3Unit of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
4Department of Biomedical and Neuromotor Sciences (DIBINEM), IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
5Unit of Rehabilitation Medicine, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy